Closed-loop neuromodulation delivers stimulation based on real-time neural feedback. Such a system requires a versatile hardware platform and advanced closed-loop algorithm. Existing platforms are either constrained by hardware capability or software programmability and are limited to a narrow parametric space during development, hindering the exploration of optimal treatment.
We distribute and integrate the control logics of BIND system across three key tiers: GUI and AI closed-loop control software, microcontroller firmware, and customized integrated circuit hardware. The software GUI sends command wirelessly to the remote platform. The central firmware seamlessly translates software commands into hardware instructions to control the customized SoC of recording system with online artifact removal, the arbitrary stimulator SoC, and the wireless module.
The BIND system enables full-duplex neural communication, delivering user-defined stimuli while simultaneously monitoring immediate changes in neural dynamics. We envision our BIND system to facilitate the closed-loop biomedical applications and advance the disease treatments.
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